Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling1
نویسندگان
چکیده
Tsutomu OKA*, Eline REMUE†‡, Kris MEERSCHAERT†‡, Berlinda VANLOO†‡, Ciska BOUCHERIE†‡, David GFELLER§, Gary D. BADER§, Sachdev S. SIDHU§, Joël VANDEKERCKHOVE†‡, Jan GETTEMANS†‡ and Marius SUDOL*‖2 *Weis Center for Research, 100 North Academy Avenue, Danville, PA 17822, U.S.A., †Department of Medical Protein Research, VIB, Ghent University, B-9000 Ghent, Belgium, ‡Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium, §Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1, and ‖Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, U.S.A.
منابع مشابه
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling.
The Hippo pathway regulates the size of organs by controlling two opposing processes: proliferation and apoptosis. YAP2 (Yes kinase-associated protein 2), one of the three isoforms of YAP, is a WW domain-containing transcriptional co-activator that acts as the effector of the Hippo pathway in mammalian cells. In addition to WW domains, YAP2 has a PDZ-binding motif at its C-terminus. We reported...
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BACKGROUND The Hippo/MST1 signaling pathway plays an important role in the regulation of cell proliferation and apoptosis. As a major downstream target of the Hippo/MST1 pathway, YAP2 (Yes-associated protein 2) functions as a transcriptional cofactor that has been implicated in many biological processes, including organ size control and cancer development. MST1/Lats kinase inhibits YAP2's nucle...
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ARVCF, an armadillo-repeat protein of the p120(ctn) family, associates with classical cadherins and is present in adherens junctions, but its function is poorly understood. Here, we show that ARVCF interacts via a C-terminal PDZ-binding motif with zonula occludens (ZO)-1 and ZO-2. ARVCF and ZO-1 partially colocalize in the vicinity of the apical adhesion complex in polarized epithelial Madin-Da...
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